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The purpose of this book is to contribute to the further development of the multidisciplinary approach to the treatment of soft tissue sarcomas. A proper diagnosis and staging remains the cornerstone of the treatment strategy. Sophisticated histopathology techniques and growing consensus on grading systems have further increased the importance of the histopathologist in providing estimates of the prognosis of the patient as well as providing data for the planning of treatment strategy. The use of cytogenetics is relatively new in this field. This might enable distinction of subgroups in specific histological tumor types. Further to this, molecular biological studies not only help to reveal inherited predispositions and details in oncogenesis in tumor development, but they may also provide additional predictive factors for tumor behaviour. Further data for the treament strategy will be provided by diagnostic imaging, in which field the role of magnetic resonance imaging is rapidly developing. As far as actual treatment is concerned, surgery still provides the major chance for cure. In view of the endeavour to be as sparing as possible, the addition of radiotherapy to surgery is of utmost importance. Usually radiotherapy is given after surgery, but the optimal sequence of the two modalities yet needs to be defined. The combined use of surgery with radiotherapy and/or chemotherapy does have an impact on wound healing. A review on recent data concerning wound healing in these situations has thus been added. There appears to be growing consensus about the role of chemotherapy in metastatic disease, where only doxorubicin, ifosfamide and DTIC are known to be active. Although it may be different for subsets, in general, single-agent chemotherapy appears to be as effecive as standard doses of combination chemotherapy. The lack of efficacy of adjuvant chemotherapy with standard doses of the drugs presently available has been shown. Just as for radiotherapy, chemotherapy may have an important role in the preoperative treatment of advanced soft tissue sarcomas, where intravenous drug administration appears to be as effective as the more complicated intraarterial administration. Thermochemotherapy, another and still investigational approach to advanced local disease, also yields interesting preliminary results. Finally, clinical behaviour, treatment strategy and the outcome of treatment in childhood soft tissue sarcomas are quite different from those in adult soft tissue sarcomas.
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Multidisciplinary Treatment of Soft Tissue Sarcomas

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This digital document is an article from NWHRC Health Center – Breast Cancer, published by Thomson Gale on March 14, 2007. The length of the article is 3027 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Breast Cancer; Treatment.
Author: Gale Reference Team
Publication: NWHRC Health Center – Breast Cancer (Pamphlet)
Date: March 14, 2007
Publisher: Thomson Gale
Page: NA

Distributed by Thomson Gale
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Breast Cancer; Treatment.: An article from: NWHRC Health Center – Breast Cancer

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The search for the most favorable therapeutic ratio – at which ablation of cancer is achieved while normal tissues are conserved – has been modern radiation oncology’s equivalent of the quest for the Holy Grail. Our awareness of the late effects of radiation grew during the past century as new modalities were introduced. Heightened normal tissue reactions accompanied the higher rates of cancer ablation achieved by escalation of radiation doses, accelerated fractionated radiotherapy, and aggressive concurrent chemotherapy and radiation regimens. This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I conference held in 2006. Written by experts in the field, it addresses a number of critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that it will assist the reader in understanding how to prevent and treat the long-term side-effects of irradiation.

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Erasmus Univ. Medical Center, Rotterdam, The Netherlands. Summarizes the recent research in the development of targeted agents in cancer therapy. Also discusses the changes in the field of q radiation therapy. Emphasizes a multidisciplinary approach. For physicians and researchers.
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